Olejar Books

Animal models provide a means to investigate fundamental mechanisms of abnormal electrical discharge i.e., seizures. Taking advantage of transgenic and homologous recombination techniques, laboratories have recently moved beyond the standard convulsant or stimulation models in rat to develop novel mouse models of epilepsy. This book provides a review of the current and emerging animal models used to study epilepsy. Prior textbooks devoted to models of seizure and epilepsy almost exclusively categorized rat models with little attention paid to these more innovative approaches. In addition, this book goes beyond animal models, including also novel approaches to epilepsy research that are just now appearing in the literature, ranging from the modeling of seizure activity in silica to a discussion of advanced strategies for seizure detection and gene therapy. These latter innovations are important as some may lead to better therapeutic treatments for patients suffering with intractable forms of epilepsy.